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At Hardy Nutritionals®, we’re deeply grateful to our community for your past donations that have helped fund groundbreaking, independent research into micronutrient therapy.
Thanks to independent researchers — and support from donors like you — over 60 peer-reviewed medical journal publications have examined the use of Daily Essential Nutrients (DEN) and previous versions of this micronutrient formula to support neurological resilience and modulate symptoms related to mood, stress, irritability, focus, and emotional regulation.
Your support today can ensure this important research continues and reaches the people who need it most.
Dr. Bonnie Kaplan has been one of the leading independent researchers to study micronutrient formulas (including Daily Essential Nutrients) and has mentored other researchers in the field of broad-spectrum micronutrient research for many years. In light of recent NIH funding cuts, she recently published a Status Report titled: Scientific Evidence Proves Nutrients are the Foundation of Brain Health on the current need for monetary donations to further critical research projects.
You can download this brief report from her website using this link: bit.ly/3I76PPD. This blog article summarizes some of her key takeaways.
“December 2025 marks the 10th anniversary of the two donor-advised charitable funds (one in Canada and one in the U.S.) that I established to raise funds for my junior academic colleagues committed to studying the potential benefit of broad-spectrum micronutrients for the treatment of mental health symptoms.
The charitable funds have been very successful — about $1M was raised and distributed, thanks to many of you reading this.
I retired from my academic position in 2016 and focused my energy on fundraising and Knowledge Translation (including coauthoring The Better Brain with Julia Rucklidge). Since then, the research on the two broad-spectrum formulas developed in Alberta has generated dozens of additional, excellent studies. But now, the funding landscape has changed, and I am reaching out to fundraise again.
Every donation is important, no matter how small. Thank you.” — Dr. Bonnie J. Kaplan
Recent NIH funding changes have created new barriers for independent academic scientists. Several active studies on DEN — including two critical research projects — are now at risk of being delayed or abandoned:
1. The North American MADDY Study (Oregon Health & Science University [OHSU], Ohio State University, and University of Lethbridge) led by Dr. Jeni Johnstone
Replicated earlier findings: about 50% of children aged 6–12 showed significant clinical benefit in a randomized placebo-controlled trial.
Next phase: funding is needed to analyze stored blood, urine, and stool samples. These biomarker studies will help identify who benefits and why, enabling personalized clinical care.
2. The New Zealand NUTRIMUM Trial led by Dr. Julia Rucklidge
Showed significant benefit for reducing perinatal mood and anxiety, lowering postnatal depression, and reducing adverse birth outcomes.
Most remarkably: infants whose mothers took micronutrients had significantly improved outcomes at 12 months.
Next step: an independent replication by teams at OHSU and Ohio State University — the expertise is ready, but funding is required.
Donate in U.S. Dollars | Donate in Canadian Dollars
Your donation goes directly toward independent, university-based studies on micronutrient treatment DEN.
Your gift helps generate data to improve clinical practices.
You support nutrition as a foundation for long-term mental wellness.
No overhead. Just direct support for research that matters.
Since the beginning, Hardy Nutritionals® has upheld a strict arm’s-length policy regarding all clinical research. We donate products for use in trials but never provide financial contributions to the studies themselves. We have no influence on how independent scientists analyze or interpret their results.
This ensures every outcome is independently produced, peer-reviewed, and unbiased by industry influence. Independent funding = trustworthy results. And that’s something we’re proud to protect.
The Micronutrients for Attention-Deficit in Youth (MADDY) study is one of the most rigorously designed trials on pediatric mental health and broad-spectrum micronutrients. Conducted across three university sites — Oregon Health & Science University, Ohio State University, and the University of Lethbridge — this double-blind, placebo-controlled trial tested DEN in children with ADHD and significant emotional dysregulation.
Children taking DEN were three times as likely to be rated “much” or “very much improved” compared to placebo. The next phase will explore:
Longer-term outcomes
Functional improvements in daily life
How micronutrients may support emotional and behavioral regulation
In parallel, the NUTRIMUM Trial needs replication to confirm initial findings that micronutrients may:
Improve symptoms of perinatal depression and anxiety
Reduce pregnancy and birth complications
Support infant brain development
Both studies also include stored biomarker samples. With funding, these can be analyzed to predict who is most likely to benefit from micronutrient therapy.
Dr. Julia Rucklidge estimates that broad implementation could save the U.S. healthcare system over $1 billion annually.
For U.S. Dollar Donations Support the Nutrition and Mental Health Research Fund: 👉 Donate in U.S. Dollars Designate your donation: “For DEN research.”
For Canadian Dollar Donations Support the Nutrition and Mental Health Fund via the Calgary Foundation: 👉 Donate in Canadian Dollars In accordance with Imagine Canada’s ethical fundraising standards. Donations administered by Calgary Foundation, 108074436RR0001, 403-802-7700.
Real Lives ImpactedYour generosity has helped create some of the most robust clinical nutrition research in the world. With your continued support, we can help reshape the future — not just in theory, but in practice. In clinics. In families. In lives.
